abstract：:We previously reported that the efficacy of photodynamic therapy (PDT) in cell culture was enhanced by ursodeoxycholic acid (UDCA), a nontoxic bile acid. In this study, we examined the ability of UDCA to promote tumor control by PDT in the mouse, using the radiation-induced fibrosarcoma tumor and the photosensitizing ...

journal_title：Photochemistry and photobiology

authors： Garbo GM,Vicente MG,Fingar V,Kessel D

更新日期：2003-10-01 00:00:00

abstract：:Using normal, untransformed, human fibroblasts, the effectiveness of aminolevulinic (ALA)-mediated photodynamic therapy (PDT) was investigated in terms of both clonogenic survival and DNA damage. The response of normal fibroblasts was then compared with Gorlin syndrome-derived fibroblasts (basal cell nevus syndrome [B...

journal_title：Photochemistry and photobiology

authors： Haylett AK,Ward TH,Moore JV

更新日期：2003-10-01 00:00:00

abstract：:To clarify the role of the Golgi apparatus in photodynamic therapy-induced apoptosis, its signaling pathway was studied after photodynamic treatment of human cervix carcinoma cell line HeLa, in which a photosensitizer, 2,4,5,7-tetrabromorhodamine 123 bromide (TBR), was incorporated into the Golgi apparatus. Laser scan...

journal_title：Photochemistry and photobiology

authors： Ogata M,Inanami O,Nakajima M,Nakajima T,Hiraoka W,Kuwabara M

更新日期：2003-09-01 00:00:00

abstract：:Dark-grown leaves of maize (Zea mays), wheat (Triticum aestivum), wild-type pea (Pisum sativum) and its light-independent photomorphogenesis mutant (lip1) have different proportions of protochlorophyllide (Pchlide) forms as revealed by low-temperature fluorescence emission spectra. Four discrete spectral forms of Pchl...

journal_title：Photochemistry and photobiology

authors： Myśliwa-Kurdziel B,Amirjani MR,Strzałka K,Sundqvist C

更新日期：2003-08-01 00:00:00

abstract：:The photocycle in photoactive yellow protein (PYP) crystals was studied by single-crystal absorption spectroscopy with experimental setups for low-temperature and time-resolved measurements. Thin and flat PYP crystals, suitable for light absorption studies, were obtained using special crystallization conditions. Illum...

journal_title：Photochemistry and photobiology

authors： Kort R,Ravelli RB,Schotte F,Bourgeois D,Crielaard W,Hellingwerf KJ,Wulff M

更新日期：2003-08-01 00:00:00

abstract：:Endogenous cellular chromophores absorb ultraviolet A radiation (UVA, 290-320 nm), the major UV component of terrestrial solar radiation, leading to the formation of reactive oxidizing species that initiate apoptosis, gene expression and mutagenesis. UVA-induced apoptosis of T helper cells is believed to underlie the ...

journal_title：Photochemistry and photobiology

authors： Zhuang S,Kochevar IE

更新日期：2003-07-01 00:00:00

abstract：:The cellular uptake, localization and efflux of meso-tetra-(4-hydroxyphenyl)porphyrin (p-THPP)-loaded nanoparticles have been studied in EMT-6 tumor cells. The effect of blood serum on photocytotoxicity has also been evaluated. Sub-130 nm nanoparticles based on poly(D,L-lactide-co-glycolide) (PLGA) (50:50 PLGA and 75:...

journal_title：Photochemistry and photobiology

authors： Konan YN,Chevallier J,Gurny R,Allémann E

更新日期：2003-06-01 00:00:00

abstract：:Dermatophytes are fungi that can cause infections (known as tinea) of the skin, hair and nails because of their ability to use keratin. Superficial mycoses are probably the most prevalent of infectious diseases worldwide. One of the most distinct limitations of the current therapeutic options is the recurrence of the ...

journal_title：Photochemistry and photobiology

authors： Smijs TG,Schuitmaker HJ

更新日期：2003-05-01 00:00:00

abstract：:A widely published expression for dipole strengths of optical transitions is found to require correction. The proposed adjustment, which involves the refractive index of the solvent in which the strengths are measured, may lead to significant changes in predictions that have been based on the equation. We discuss a cl...

journal_title：Photochemistry and photobiology

authors： Knox RS

更新日期：2003-05-01 00:00:00

abstract：:Exposure to ultraviolet radiation results in increased levels of intradermal cis-urocanic acid (cUCA) and alters cutaneous immunity by interfering with processing and presentation of antigen by Langerhans cells. Reports on effects of systemic immunotoxicity with 30 day cUCA exposure in laboratory rodents include thymi...

journal_title：Photochemistry and photobiology

authors： Prater MR,Gogal RM Jr,De Fabo EC,Longstreth J,Holladay SD

更新日期：2003-04-01 00:00:00

abstract：:The intrinsic autofluorescence properties of biological tissues can be affected by the occurrence of histological and biochemical alterations induced by pathological processes. In this study the potential of autofluorescence to distinguish tumor from normal tissues was investigated with the view of a real-time diagnos...

journal_title：Photochemistry and photobiology

authors： Croce AC,Fiorani S,Locatelli D,Nano R,Ceroni M,Tancioni F,Giombelli E,Benericetti E,Bottiroli G

更新日期：2003-03-01 00:00:00

abstract：:N2-hydroxyisocytosine and 1-methyl-N2-hydroxyisocytosine were studied using a matrix isolation technique combined with infrared absorption spectroscopy. For N2-hydroxyisocytosine isolated in an Ar matrix (at 10 K), two imino-oxo isomers, one with the hydroxyimino =N-OH group directed toward the N1-H group (the form ca...

journal_title：Photochemistry and photobiology

authors： Lapinski L,Nowak MJ,Kwiatkowski JS,Leszczynski J

更新日期：2003-03-01 00:00:00

abstract：:Fabrea salina is a marine ciliate that shows photomotile responses such as positive phototaxis and a step-down photophobic reaction. We found that preilluminated F. salina cells show a phototactic response significantly greater than that of dark-adapted cells when exposed to the same phototactic light stimulus. In par...

journal_title：Photochemistry and photobiology

authors： Marangoni R,Colombetti G

更新日期：2003-02-01 00:00:00

abstract：:The multifunctional polypeptide cyclosporin synthetase (CySyn) remains one of the most complex nonribosomal peptide synthetase described. In this study we used a highly specific photoaffinity labeling procedure with the natural cofactor S-adenosyl-L-methionine (AdoMet), 14C-isotopically labeled at the Sdelta methyl gr...

journal_title：Photochemistry and photobiology

authors： Velkov T,Lawen A

更新日期：2003-02-01 00:00:00

abstract：:Phototropin is a blue light-activated photoreceptor that plays a dominant role in the phototropism of plants. The protein contains two subunits that bind flavin mononucleotide (FMN), which are responsible for the initial steps of the light-induced reaction. It has been proposed that the photoexcited flavin molecule ad...

journal_title：Photochemistry and photobiology

authors： Neiss C,Saalfrank P

更新日期：2003-01-01 00:00:00

abstract：:The UV radiation environment on planetary surfaces and within atmospheres is of importance in a wide range of scientific disciplines. Solar UV radiation is a driving force of chemical and organic evolution and serves also as a constraint in biological evolution. In this work we modeled the transmission of present and ...

journal_title：Photochemistry and photobiology

authors： Rontó G,Bérces A,Lammer H,Cockell CS,Molina-Cuberos GJ,Patel MR,Selsis F

更新日期：2003-01-01 00:00:00

abstract：:Protoporphyrin IX dimethyl ester (PME), a dimethyl esterification of protoporphyrin IX (PpIX), exhibits higher intracellular uptake into NPC/CNE2 cells, a poorly differentiated human nasopharyngeal carcinoma, than does PpIX. Phototoxicity studies reveal PME to be a more potent photosensitizer than is PpIX, at the earl...

journal_title：Photochemistry and photobiology

authors： Yee KK,Soo KC,Bay BH,Olivo M

更新日期：2002-12-01 00:00:00

abstract：:Ring-fused retinal analogs were designed to examine the hula-twist mode of the photoisomerization of the 9-cis retinylidene chromophore. Two 9-cis retinal analogs, the C11-C13 five-membered ring-fused and the C12-C14 five-membered ring-fused retinal derivatives, formed the pigments with opsin. The C11-C13 ring-fused a...

journal_title：Photochemistry and photobiology

authors： Hirano T,Lim IT,Kim DM,Zheng XG,Yoshihara K,Oyama Y,Imai H,Shichida Y,Ishiguro M

更新日期：2002-12-01 00:00:00

abstract：:Among beetle luciferases, the pH-sensitive firefly luciferases have been studied extensively. Much less is known about pH-insensitive luciferases, which include click beetle and railroad worm luciferases. Previously, we found that the residues R215 and T226 (N230) are important for green light emission. Here we show t...

journal_title：Photochemistry and photobiology

authors： Viviani VR,Uchida A,Viviani W,Ohmiya Y

更新日期：2002-11-01 00:00:00

abstract：:The design, synthesis and application of a new fluorescent-labeling reagent for collagen has been developed as a prerequisite for the design of a photoactivated collagen-crosslinking compound for surgical wound closure. The amine groups in collagen are the targets of a rational design for a new fluorophore because nat...

journal_title：Photochemistry and photobiology

authors： Timberlake GT,Reddy GK,Stehno-Bittel L,Weber JF,Amslinger S,Givens RS

更新日期：2002-11-01 00:00:00

abstract：:To determine the origin of the UV-specific CC to TT tandem mutation at the CC site, we made a duplex DNA decamer containing a uracil cis-syn cyclobutane dimer (CBD) as the deaminated model of a cytosine dimer. Two-dimensional 1H-NMR spectroscopy studies were performed on this sequence where two adenines (Ade) were opp...

journal_title：Photochemistry and photobiology

authors： Lee HM,Kim JK

更新日期：2002-10-01 00:00:00

abstract：:We have been able to identify a blue fluorophore from the low-molecular weight soluble fraction of human adult nondiabetic brunescent cataract lenses as xanthurenic acid 8-O-beta-D-glucoside (XA8OG) (excitation = 338 nm and emission = 440 nm). To determine the role of this fluorophore in the lens, we have examined its...

journal_title：Photochemistry and photobiology

authors： Thiagarajan G,Shirao E,Ando K,Inoue A,Balasubramanian D

更新日期：2002-09-01 00:00:00

abstract：:We calculated the integrated UVB and plant damage irradiances for Argentina, a country in the Southern Hemisphere spread over a large latitudinal range. The irradiances were calculated for clear sky days using the Madronich code for the average conditions of the months corresponding to the summer and winter solstices ...

journal_title：Photochemistry and photobiology

authors： Micheletti MI,Piacentini RD

更新日期：2002-09-01 00:00:00

abstract：:Photodynamic therapy (PDT) using the second-generation photosensitizer phthalocyanine (Pc) 4 causes mitochondrial damage and induces apoptosis through the release of cytochrome c to the cytosol. Another protein of the mitochondrial intermembrane space, Smac/DIABLO (second mitochondria-derived activator of caspase/dire...

journal_title：Photochemistry and photobiology

authors： Usuda J,Chiu SM,Azizuddin K,Xue LY,Lam M,Nieminen AL,Oleinick NL

更新日期：2002-08-01 00:00:00

abstract：:The synthesis of a molecule containing hypericin and luciferin moieties joined by a tether is reported. The light-induced (in vitro) antiviral activity as well as the photophysical properties of this new compound are measured and compared with those of the parent compounds, hypericin and pseudohypericin. This tethered...

journal_title：Photochemistry and photobiology

authors： Wen J,Chowdhury P,Wills NJ,Wannemuehler Y,Park J,Kesavan S,Carpenter S,Kraus GA,Petrich JW

更新日期：2002-08-01 00:00:00

abstract：:Inflammatory stimuli result in the production of cutaneous eicosanoids, which are known to contribute to the process of tumor promotion. Cyclooxygenase (COX), the rate-limiting enzyme for the production of prostaglandins (PG) from arachidonic acid, exists in at least two isoforms, COX-1 and COX-2. COX-1 is constitutiv...

journal_title：Photochemistry and photobiology

authors： An KP,Athar M,Tang X,Katiyar SK,Russo J,Beech J,Aszterbaum M,Kopelovich L,Epstein EH Jr,Mukhtar H,Bickers DR

更新日期：2002-07-01 00:00:00

abstract：:A novel type of circadian and photoperiodic control of the cell division cycle was found in photoautotrophic Euglena gracilis. When algae entrained to 24 h light-dark (LD) cycles (14 h L) were transferred to continuous darkness (DD) at the eighth hour of the final LD photoperiod, cell-cycle transition was arrested in ...

journal_title：Photochemistry and photobiology

authors： Hagiwara SY,Bolige A,Zhang Y,Takahashi M,Yamagishi A,Goto K

更新日期：2002-07-01 00:00:00

abstract：:The retinal protonated Schiff base of bacteriorhodopsin is photoreactive to reducing agents such as NaBH4. In the present work we have studied the effect of different protein hydration levels on the photoreductive reaction, as well as the consequences of preventing isomerization around the critical C13=C14 retinal dou...

journal_title：Photochemistry and photobiology

authors： Aharoni A,Ottolenghi M,Sheves M

更新日期：2002-06-01 00:00:00

abstract：:The photoluminescence (PL) of CdSe quantum dots (QD) in aqueous media has been studied in the presence of gold nanoparticles (NP) with different shapes. The steady state PL intensity of CdSe QD (1.5-2 nm in size) is quenched in the presence of gold NP. Picosecond bleach recovery and nanosecond time-resolved luminescen...

journal_title：Photochemistry and photobiology

authors： Nikoobakht B,Burda C,Braun M,Hun M,El-Sayed MA

更新日期：2002-06-01 00:00:00

abstract：:It is generally assumed that a central metal is essential for the efficiency of phthalocyanines in photodynamic therapy (PDT) of cancer. Contrary to the set opinion, the results of the present study indicate that the metal-free sulfonated phthalocyanines (H2PcSn, where n is the number of sulfonate groups per molecule)...

journal_title：Photochemistry and photobiology

authors： Feofanov A,Grichine A,Karmakova T,Kazachkina N,Pecherskih E,Yakubovskaya R,Luk'yanets E,Derkacheva V,Egret-Charlier M,Vigny P

更新日期：2002-05-01 00:00:00

abstract：:1-Hydroxybenzotriazole and 1-hydroxypyridine-2-thione were incorporated as ligands with the cluster Ru3(CO)10 (NCMe)2 to give [(mu-H)Ru3(CO)10(mu2-2,3-eta2-NNN(O)C6 H4)] and [(mu-H)Ru3(CO)9(mu2-eta1 : eta2-C5H4N(O)S)], respectively. Irradiation of these two new triruthenium metal clusters individually with 350 nm UV l...

journal_title：Photochemistry and photobiology

authors： Hwu JR,Kuang-Lieh L,Yu SF,Yu LJ,Kumaresan S,Lin KJ,Tsay SC

更新日期：2002-05-01 00:00:00

abstract：:In current clinical practice, photodynamic therapy (PDT) is carried out with prescribed drug doses and light doses as well as fixed drug-light intervals and illumination fluence rates. This approach can result in undesirable treatment outcomes of either overtreatment or undertreatment because of biological variations ...

journal_title：Photochemistry and photobiology

authors： Zeng H,Korbelik M,McLean DI,MacAulay C,Lui H

更新日期：2002-04-01 00:00:00

abstract：:Absolute fluorescence quantum yields are reported for the rhodamine 6G cation and the fluorescein dianion dyes in nine solvents. This information is combined with previously reported fluorescence lifetimes to deduce radiative and nonradiative decay rates. Along the alcohol series from methanol to octanol, rhodamine 6G...

journal_title：Photochemistry and photobiology

authors： Magde D,Wong R,Seybold PG

更新日期：2002-04-01 00:00:00

abstract：:Consecutive spectral analyses of ultraweak photon emission from sweet potato showing a defense response were conducted to observe the process of physiological transition. The spectrum showed a drastic transition from 2 to 10 h after inoculation with Fusarium oxysporum, during which the emission intensity increased slo...

journal_title：Photochemistry and photobiology

authors： Iyozumi H,Kato K,Makino T

更新日期：2002-03-01 00:00:00

abstract：:The synthesis, characterization and photophysical properties of two perfluoroalkyl (5,10,15,20-tetrakis-[trifluoromethyl]- and [heptafluoropropyl]-porphyrin) and two perfluoroaryl (5,10,15,20-tetrakis-[2,6-difluorophenyl]- and [pentafluorophenyl]-porphyrin) are described, with reference to their potential in both phot...

journal_title：Photochemistry and photobiology

authors： Grancho JC,Pereira MM,Miguel Mda G,Rocha GA,Burrows HD

更新日期：2002-03-01 00:00:00

abstract：:Flash-induced absorbance spectroscopy was used to analyze the proton uptake and electron transfer properties of photosynthetic reaction centers (RC) of Rhodobacter capsulatus that have been genetically modified near the primary quinone electron acceptor (Q(A)). M246Ala and M247Ala, which are symmetry-related to the po...

journal_title：Photochemistry and photobiology

authors： Tandori J,Miksovska J,Valerio-Lepiniec M,Schiffer M,Maróti P,Hanson DK,Sebban P

更新日期：2002-02-01 00:00:00

abstract：:Restenosis results from intimal hyperplasia and constrictive remodeling following cardiovascular interventions. Photodynamic therapy (PDT) has been shown to inhibit intimal hyperplasia in vivo by preventing neointimal repopulation of the treated vessel. This study was undertaken in an attempt to further dissect the me...

journal_title：Photochemistry and photobiology

authors： Waterman PR,Overhaus M,Heckenkamp J,Nigri GR,Fungaloi PF,Landis ME,Kossodo SC,LaMuraglia GM

更新日期：2002-01-01 00:00:00

abstract：:Unidirectional blue light directs the rhizoid-thallus axis in the apolar zygote of the brown alga, Silvetia compressa. This effect is mediated by an increase in the intracellular concentration of guanosine 3', 5'-cyclic monophosphate. In this study we show the identification of a rhodopsin-like protein, by means of an...

journal_title：Photochemistry and photobiology

authors： Gualtieri P,Robinson KR

更新日期：2002-01-01 00:00:00

abstract：:We report that exo- and endogenous guanosine 3',5'-cyclic monophosphate (cGMP) specifically influenced the photophobic response. In behavioral experiments the slowly hydrolyzable and membrane-permeable analogs of cGMP (8-bromo-cGMP [Br-cGMP] and N6,2'-o-dibutyryl-cGMP) dramatically prolonged the time for ciliary stop ...

journal_title：Photochemistry and photobiology

authors： Walerczyk M,Fabczak S

更新日期：2001-12-01 00:00:00

abstract：:The azide ion is a strong physical quencher of singlet molecular oxygen (1O2) and is frequently employed to show involvement of 1O2 in oxidation processes. Rate constants (k(q)) for the quenching of 1O2 by azide are routinely used as standards to calculate k(q) values for quenching by other substrates. We have measure...

journal_title：Photochemistry and photobiology

authors： Li MY,Cline CS,Koker EB,Carmichael HH,Chignell CF,Bilski P

更新日期：2001-12-01 00:00:00